ECM2026, 14-17 June 2026, Copenhagen, DenmarkAlexandra Naba, Associate Professor, Department of Physiology and Biophysics, University of Illinois Chicago, Member, University of Illinois Cancer Center Founder, The Matrisome Project
Abstract: The extracellular matrix (ECM) is a complex meshwork of proteins that constitutes the architectural framework of multicellular organisms. It provides mechanical and biochemical cues that trigger molecular pathways orchestrating tissue organization and cellular functions. Importantly, alterations in the composition, structure, and signaling properties of the ECM contribute to cancer progression. Thus, a better characterization of ECM composition, metabolism, and biology can lead to the identification of novel prognostic and diagnostic markers and therapeutic opportunities [1].
In this talk, I will present the latest proteomic methods developed in my laboratory to characterize the “matrisome” of healthy and diseased tissue microenvironments [2]. I will then discuss how these methods can be applied to identify 1) ECM biomarkers for better patient stratification and 2) novel ECM proteins promoting cancer progression that can further be used as targets of matritherapies [3]. In the last part of my talk, I will discuss remaining technological challenges and knowledge gaps in ECM research and propose avenues to address them to accelerate the path to translational ECM research.
References
1. Naba A. Mechanisms of assembly and remodelling of the extracellular matrix. Nat Rev Mol Cell Biol. 2024;25:865–85.
2. Naba A. Ten years of extracellular matrix proteomics: Accomplishments, challenges, and future perspectives. Mol Cell Prot. 2023;22:100528.
